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Heparan sulfate proteoglycans mediate prion-like α-synuclein toxicity in Parkinson’s in vivo models

Parkinson’s disease (PD) is a debilitating neurodegenerative disorder characterized by progressive motor decline and the aggregation of α-synuclein protein. Growing evidence suggests that α-synuclein aggregates may spread from neurons of the digestive tract to the central nervous system in a prion-l...

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Detalles Bibliográficos
Autores principales: Chen, Merry, Vincent, Julie, Ezeanii, Alexis, Wakade, Saurabh, Yerigenahally, Shobha, Mor, Danielle E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259873/
https://www.ncbi.nlm.nih.gov/pubmed/35790300
http://dx.doi.org/10.26508/lsa.202201366