Dimethyl Fumarate Blocks Tumor Necrosis Factor-Alpha-Driven Inflammation and Metabolic Rewiring in the Retinal Pigment Epithelium

The retinal pigment epithelium (RPE) acts as a metabolic gatekeeper between photoreceptors and the choroidal vasculature to maintain retinal function. RPE dysfunction is a key feature of age-related macular degeneration (AMD), the leading cause of blindness in developed countries. Inflammation is a...

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Detalles Bibliográficos
Autores principales: Shu, Daisy Y., Frank, Scott I., Fitch, Tessa C., Karg, Margarete M., Butcher, Erik R., Nnuji-John, Emmanuella, Kim, Leo A., Saint-Geniez, Magali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259930/
https://www.ncbi.nlm.nih.gov/pubmed/35813071
http://dx.doi.org/10.3389/fnmol.2022.896786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259930/
https://www.ncbi.nlm.nih.gov/pubmed/35813071
http://dx.doi.org/10.3389/fnmol.2022.896786

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