Cargando…

Dimethyl Fumarate Blocks Tumor Necrosis Factor-Alpha-Driven Inflammation and Metabolic Rewiring in the Retinal Pigment Epithelium

The retinal pigment epithelium (RPE) acts as a metabolic gatekeeper between photoreceptors and the choroidal vasculature to maintain retinal function. RPE dysfunction is a key feature of age-related macular degeneration (AMD), the leading cause of blindness in developed countries. Inflammation is a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shu, Daisy Y., Frank, Scott I., Fitch, Tessa C., Karg, Margarete M., Butcher, Erik R., Nnuji-John, Emmanuella, Kim, Leo A., Saint-Geniez, Magali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Molecular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259930/ https://www.ncbi.nlm.nih.gov/pubmed/35813071 http://dx.doi.org/10.3389/fnmol.2022.896786

Ejemplares similares

Suppression of PGC-1α Drives Metabolic Dysfunction in TGFβ2-Induced EMT of Retinal Pigment Epithelial Cells
por: Shu, Daisy Y., et al.
Publicado: (2021)

Identification of a synergistic interaction between endothelial cells and retinal pigment epithelium
por: Spencer, Carrie, et al.
Publicado: (2017)

Microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health
por: Karg, Margarete M., et al.
Publicado: (2023)

Correction: Microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health
por: Karg, Margarete M., et al.
Publicado: (2023)

EMT and EndMT: Emerging Roles in Age-Related Macular Degeneration
por: Shu, Daisy Y., et al.
Publicado: (2020)

Dimethyl Fumarate Protects Retinal Pigment Epithelium from Blue Light-Induced Oxidative Damage via the Nrf2 Pathway
por: Shimizu, Hideyuki, et al.
Publicado: (2022)

Heat treatment of retinal pigment epithelium induces production of elastic lamina components and antiangiogenic activity
por: Sekiyama, Eiichi, et al.
Publicado: (2012)

Divergent Metabolomic Signatures of TGFβ2 and TNFα in the Induction of Retinal Epithelial-Mesenchymal Transition
por: Ng, Pei Qin, et al.
Publicado: (2023)

Pharmaceutical Induction of PGC-1α Promotes Retinal Pigment Epithelial Cell Metabolism and Protects against Oxidative Damage
por: Satish, Sangeeta, et al.
Publicado: (2018)

Dimethyl fumarate for ischemic stroke
por: Kunze, Reiner
Publicado: (2017)

Chronic exposure to tumor necrosis factor alpha induces retinal pigment epithelium cell dedifferentiation
por: Touhami, Sara, et al.
Publicado: (2018)

Dimethyl Fumarate and Monomethyl Fumarate Promote Post-Ischemic Recovery in Mice
por: Yao, Yang, et al.
Publicado: (2016)

Effects of dimethyl fumarate on neuroprotection and immunomodulation
por: Albrecht, Philipp, et al.
Publicado: (2012)

Dimethyl fumarate mitigates optic neuritis
por: Zyla, Katarzyna, et al.
Publicado: (2019)

Dimethyl fumarate transfer into human milk
por: Ciplea, Andrea I., et al.
Publicado: (2020)

Drug-Repurposing Strategy for Dimethyl Fumarate
por: Giunta, Salvatore, et al.
Publicado: (2023)

Correction: Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration
por: Rosales, Mariana Aparecida Brunini, et al.
Publicado: (2019)

Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration
por: Rosales, Mariana Aparecida Brunini, et al.
Publicado: (2019)

Immunological Predictors of Dimethyl Fumarate‐Induced Lymphopenia
por: Diebold, Martin, et al.
Publicado: (2022)

Dimethyl fumarate for treating Papillon–Lefèvre syndrome
por: Al-Omair, Abdullah, et al.
Publicado: (2022)

The Challenge of Dimethyl Fumarate Repurposing in Eye Pathologies
por: Manai, Federico, et al.
Publicado: (2022)

The Pleiotropic Effects of Fumarate: From Mitochondrial Respiration to Epigenetic Rewiring and DNA Repair Mechanisms
por: Giallongo, Sebastiano, et al.
Publicado: (2023)

Pharmacokinetics and Bioavailability of Monomethyl Fumarate Following a Single Oral Dose of Bafiertam™ (Monomethyl Fumarate) or Tecfidera(®) (Dimethyl Fumarate)
por: Lategan, Thomas W., et al.
Publicado: (2021)

TNFα induced by DNA-sensing in macrophage compromises retinal pigment epithelial (RPE) barrier function
por: Twarog, Michael, et al.
Publicado: (2023)

Beneficial actions of the anti-inflammatory dimethyl fumarate in glioblastomas
por: Ghods, Ali J., et al.
Publicado: (2013)

Dimethyl fumarate modulates antioxidant and lipid metabolism in oligodendrocytes
por: Huang, He, et al.
Publicado: (2015)

Prevention of Autoimmune Diabetes in NOD Mice by Dimethyl Fumarate
por: Li, Shiri, et al.
Publicado: (2021)

Effectiveness and safety of dimethyl fumarate in progressive multiple sclerosis
por: Moreira Ferreira, Vanessa F, et al.
Publicado: (2021)

Comparison of dimethyl fumarate and interferon outcomes in an MS cohort
por: Sattarnezhad, Neda, et al.
Publicado: (2022)

ALKBH7 mediates necrosis via rewiring of glyoxal metabolism
por: Kulkarni, Chaitanya A, et al.
Publicado: (2020)

Bestrophin 2 is expressed in human non-pigmented ciliary epithelium but not retinal pigment epithelium
por: Zhang, Youwen, et al.
Publicado: (2010)

Distributed rewiring model for complex networking: The effect of local rewiring rules on final structural properties
por: López Chavira, Magali Alexander, et al.
Publicado: (2017)

Dimethyl Fumarate Induces Glutathione Recycling by Upregulation of Glutathione Reductase
por: Hoffmann, Christina, et al.
Publicado: (2017)

Dimethyl fumarate-associated lymphopenia: Risk factors and clinical significance
por: Longbrake, Erin E, et al.
Publicado: (2015)

Immune response to vaccines is maintained in patients treated with dimethyl fumarate
por: von Hehn, Christian, et al.
Publicado: (2017)

Impaired T-cell migration to the CNS under fingolimod and dimethyl fumarate
por: Mathias, Amandine, et al.
Publicado: (2017)

Characterization of lymphopenia in patients with MS treated with dimethyl fumarate and fingolimod
Publicado: (2018)

Discontinuation and comparative effectiveness of dimethyl fumarate and fingolimod in 2 centers
por: Vollmer, Brandi, et al.
Publicado: (2018)

Characterization of lymphopenia in patients with MS treated with dimethyl fumarate and fingolimod
por: Nakhaei-Nejad, Maryam, et al.
Publicado: (2017)

Comparative effectiveness of teriflunomide vs dimethyl fumarate in multiple sclerosis
por: Laplaud, David-Axel, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ltq155kosasocssdgdu06qhvg4