S645C Point Mutation Suppresses Degradation of EGFR to Promote Progression of Glioblastoma

BACKGROUND: The tightly controlled activity of EGFR is important for the homeostasis of self-renewal of human tissue. Mutations in the extracellular domain of EGFR are frequent and function as a novel mechanism for oncogenic EGFR activation in GBM, and impact the response of patients to small-molecu...

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Detalles Bibliográficos
Autores principales: Huang, Wenda, Zou, Ling, Hao, Zhaonian, Wang, Baofeng, Mao, Feng, Duan, Qiuhong, Guo, Dongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259983/
https://www.ncbi.nlm.nih.gov/pubmed/35814475
http://dx.doi.org/10.3389/fonc.2022.904383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259983/
https://www.ncbi.nlm.nih.gov/pubmed/35814475
http://dx.doi.org/10.3389/fonc.2022.904383

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