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S645C Point Mutation Suppresses Degradation of EGFR to Promote Progression of Glioblastoma
BACKGROUND: The tightly controlled activity of EGFR is important for the homeostasis of self-renewal of human tissue. Mutations in the extracellular domain of EGFR are frequent and function as a novel mechanism for oncogenic EGFR activation in GBM, and impact the response of patients to small-molecu...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259983/ https://www.ncbi.nlm.nih.gov/pubmed/35814475 http://dx.doi.org/10.3389/fonc.2022.904383 |