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The N Terminus of Adhesion G Protein–Coupled Receptor GPR126/ADGRG6 as Allosteric Force Integrator

The adhesion G protein–coupled receptor (aGPCR) GPR126/ADGRG6 plays an important role in several physiological functions, such as myelination or peripheral nerve repair. This renders the receptor an attractive pharmacological target. GPR126 is a mechano-sensor that translates the binding of extracel...

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Detalles Bibliográficos
Autores principales: Mitgau, Jakob, Franke, Julius, Schinner, Camilla, Stephan, Gabriele, Berndt, Sandra, Placantonakis, Dimitris G., Kalwa, Hermann, Spindler, Volker, Wilde, Caroline, Liebscher, Ines
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259995/
https://www.ncbi.nlm.nih.gov/pubmed/35813217
http://dx.doi.org/10.3389/fcell.2022.873278