Cargando…

Single-cell RNA sequencing reveals that BMPR2 mutation regulates right ventricular function via ID genes

BACKGROUND: Mutations in bone morphogenetic protein type II receptor (BMPR2) have been found in patients with congenital heart disease-associated pulmonary arterial hypertension (CHD-PAH). Our study aimed to clarify whether deficient BMPR2 signalling acts through downstream effectors, inhibitors of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Du, Mingxia, Jiang, Haibin, Liu, Hongxian, Zhao, Xin, Zhou, Yu, Zhou, Fang, Piao, Chunmei, Xu, Guoqiang, Ma, Feng, Wang, Jianan, Perros, Frederic, Morrell, Nicholas W., Gu, Hong, Yang, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Respiratory Society 2022
Materias:	Original Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260124/ https://www.ncbi.nlm.nih.gov/pubmed/34857612 http://dx.doi.org/10.1183/13993003.00327-2021

Ejemplares similares

The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations
por: Dunmore, Benjamin J., et al.
Publicado: (2013)

Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2
por: Novoyatleva, Tatyana, et al.
Publicado: (2021)

Author Correction: Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2
por: Novoyatleva, Tatyana, et al.
Publicado: (2022)

Targeting translational read-through of premature termination mutations in BMPR2 with PTC124 for pulmonary arterial hypertension
por: Long, Lu, et al.
Publicado: (2020)

Different Cytokine Patterns in BMPR2-Mutation-Positive Patients and Patients With Pulmonary Arterial Hypertension Without Mutations and Their Influence on Survival
por: Schwiening, Max, et al.
Publicado: (2022)

The promise of recombinant BMP ligands and other approaches targeting BMPR-II in the treatment of pulmonary arterial hypertension
por: Ormiston, Mark L., et al.
Publicado: (2015)

Physiologic and molecular consequences of endothelial Bmpr2 mutation
por: Majka, Susan, et al.
Publicado: (2011)

BMPR2 mutations and survival in pulmonary arterial hypertension: an individual participant data meta-analysis
por: Evans, Jonathan D W, et al.
Publicado: (2016)

Oxidative injury is a common consequence of BMPR2 mutations
por: Lane, Kirk L., et al.
Publicado: (2011)

BMPR1B mutation causes Pierre Robin sequence
por: Yang, Yongjia, et al.
Publicado: (2017)

A Rare Case of Isolated Right Ventricular Non-compaction With the Novel TTN Mutation
por: Huang, Piao-piao, et al.
Publicado: (2022)

ID proteins promote the survival and primed-to-naive transition of human embryonic stem cells through TCF3-mediated transcription
por: Jiang, Haibin, et al.
Publicado: (2022)

Sequential combination therapy with parenteral prostacyclin in BMPR2 mutations carriers
por: Boucly, Athénaïs, et al.
Publicado: (2022)

Homozygous missense variant in BMPR1A resulting in BMPR signaling disruption and syndromic features
por: Russell, Bianca E., et al.
Publicado: (2019)

Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling
por: Pickworth, Josephine, et al.
Publicado: (2017)

Expression of mutant BMPR-II in pulmonary endothelial cells promotes apoptosis and a release of factors that stimulate proliferation of pulmonary arterial smooth muscle cells
por: Yang, Xudong, et al.
Publicado: (2011)

Treatment of right ventricular perforation during percutaneous coronary intervention
por: Gu, Guoqiang, et al.
Publicado: (2015)

Hematopoietic stem cell transplantation alters susceptibility to pulmonary hypertension in Bmpr2-deficient mice
por: Crosby, Alexi, et al.
Publicado: (2018)

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension
por: Long, Lu, et al.
Publicado: (2015)

A Novel BMPR2 Mutation Associated with Pulmonary Arterial Hypertension in an Octogenarian
por: Johri, Shilpa, et al.
Publicado: (2010)

Functional Changes in Pulmonary Arterial Endothelial Cells Associated with BMPR2 Mutations
por: Wang, Hu, et al.
Publicado: (2014)

Three novel BMPR2 mutations associated with advanced pulmonary arterial hypertension
por: Hara, Hironori, et al.
Publicado: (2017)

15 years journey of idiopathic pulmonary arterial hypertension with BMPR2 mutation
por: Ahn, Kyung Jin, et al.
Publicado: (2019)

BMPR2 mutations and response to inhaled or parenteral prostanoids: a case series
por: Scelsi, Laura, et al.
Publicado: (2021)

Screening for pulmonary arterial hypertension in adults carrying a BMPR2 mutation
por: Montani, David, et al.
Publicado: (2021)

Two Birds with One Stone: Helping the Pulmonary Arteries and the Right Ventricle by Targeting BMPR2 Signaling
por: Lee, Michael H., et al.
Publicado: (2021)

Hemodynamic and clinical onset in patients with hereditary pulmonary arterial hypertension and BMPR2 mutations
por: Pfarr, Nicole, et al.
Publicado: (2011)

Mutation in BMPR2 Promoter: A ‘Second Hit’ for Manifestation of Pulmonary Arterial Hypertension?
por: Viales, Rebecca Rodríguez, et al.
Publicado: (2015)

A hypomorphic BMPR1B mutation causes du Pan acromesomelic dysplasia
por: Stange, Katja, et al.
Publicado: (2015)

Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension
por: Chaikuad, Apirat, et al.
Publicado: (2019)

Is iron deficiency caused by BMPR2 mutations or dysfunction in pulmonary arterial hypertension patients?
por: Theobald, Vivienne, et al.
Publicado: (2023)

A potential adverse role for leptin and cardiac leptin receptor in the right ventricle in pulmonary arterial hypertension: effect of metformin is BMPR2 mutation-specific
por: Talati, Megha, et al.
Publicado: (2023)

Rapid instructional design: learning ID fast and right
por: Piskurich, George M
Publicado: (2015)

BMPR2 Variants Underlie Nonsyndromic Oligodontia
por: Zheng, Jinglei, et al.
Publicado: (2023)

BMPR2 expression is suppressed by signaling through the estrogen receptor
por: Austin, Eric D, et al.
Publicado: (2012)

Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension
por: Austin, Eric D, et al.
Publicado: (2009)

Absence of influence of gender and BMPR2 mutation type on clinical phenotypes of pulmonary arterial hypertension
por: Girerd, Barbara, et al.
Publicado: (2010)

BMPR2 mutations and endothelial dysfunction in pulmonary arterial hypertension (2017 Grover Conference Series)
por: Frump, Andrea, et al.
Publicado: (2018)

Mutation in Bmpr1b Leads to Optic Disc Coloboma and Ventral Retinal Gliosis in Mice
por: Yan, Xiaohe, et al.
Publicado: (2020)

Gender differences in pulmonary arterial hypertension patients with BMPR2 mutation: a meta-analysis
por: Ge, Xiaoyue, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_mse51lkn7t0qa82efhmt12j9rg