Blocking the Farnesyl Pocket of PDEδ Reduces Rheb-Dependent mTORC1 Activation and Survival of Tsc2-Null Cells

Rheb is a small GTPase member of the Ras superfamily and an activator of mTORC1, a protein complex master regulator of cell metabolism, growth, and proliferation. Rheb/mTORC1 pathway is hyperactivated in proliferative diseases, such as Tuberous Sclerosis Complex syndrome and cancer. Therefore, targe...

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Detalles Bibliográficos
Autores principales: Armijo, Marisol Estrella, Escalona, Emilia, Peña, Daniela, Farias, Alejandro, Morin, Violeta, Baumann, Matthias, Klebl, Bert Matthias, Pincheira, Roxana, Castro, Ariel Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260180/
https://www.ncbi.nlm.nih.gov/pubmed/35814251
http://dx.doi.org/10.3389/fphar.2022.912688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260180/
https://www.ncbi.nlm.nih.gov/pubmed/35814251
http://dx.doi.org/10.3389/fphar.2022.912688

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