An overview of the BOIN design and its current extensions for novel early-phase oncology trials

Bayesian Optimal Interval (BOIN) designs are a class of model-assisted dose-finding designs that can be used in oncology trials to determine the maximum tolerated dose (MTD) of a study drug based on safety or the optimal biological dose (OBD) based on safety and efficacy. BOIN designs provide a comp...

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Detalles Bibliográficos
Autores principales: Ananthakrishnan, Revathi, Lin, Ruitao, He, Chunsheng, Chen, Yanping, Li, Daniel, LaValley, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260438/
https://www.ncbi.nlm.nih.gov/pubmed/35812822
http://dx.doi.org/10.1016/j.conctc.2022.100943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260438/
https://www.ncbi.nlm.nih.gov/pubmed/35812822
http://dx.doi.org/10.1016/j.conctc.2022.100943

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