Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity

[Image: see text] There is a pressing need for host-directed therapeutics that elicit broad-spectrum antiviral activities to potentially address current and future viral pandemics. Apratoxin S4 (Apra S4) is a potent Sec61 inhibitor that prevents cotranslational translocation of secretory proteins in...

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Detalles Bibliográficos
Autores principales: Pohl, Marie O., Martin-Sancho, Laura, Ratnayake, Ranjala, White, Kris M., Riva, Laura, Chen, Qi-Yin, Lieber, Gauthier, Busnadiego, Idoia, Yin, Xin, Lin, Samuel, Pu, Yuan, Pache, Lars, Rosales, Romel, Déjosez, Marion, Qin, Yiren, De Jesus, Paul D., Beall, Anne, Yoh, Sunnie, Hale, Benjamin G., Zwaka, Thomas P., Matsunaga, Naoko, García-Sastre, Adolfo, Stertz, Silke, Chanda, Sumit K., Luesch, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260726/
https://www.ncbi.nlm.nih.gov/pubmed/35766385
http://dx.doi.org/10.1021/acsinfecdis.2c00008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260726/
https://www.ncbi.nlm.nih.gov/pubmed/35766385
http://dx.doi.org/10.1021/acsinfecdis.2c00008

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