Distinct cell type-specific protein signatures in GRN and MAPT genetic subtypes of frontotemporal dementia

Frontotemporal dementia is characterized by progressive atrophy of frontal and/or temporal cortices at an early age of onset. The disorder shows considerable clinical, pathological, and genetic heterogeneity. Here we investigated the proteomic signatures of frontal and temporal cortex from brains wi...

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Detalles Bibliográficos
Autores principales: Miedema, Suzanne S. M., Mol, Merel O., Koopmans, Frank T. W., Hondius, David C., van Nierop, Pim, Menden, Kevin, de Veij Mestdagh, Christina F., van Rooij, Jeroen, Ganz, Andrea B., Paliukhovich, Iryna, Melhem, Shamiram, Li, Ka Wan, Holstege, Henne, Rizzu, Patrizia, van Kesteren, Ronald E., van Swieten, John C., Heutink, Peter, Smit, August B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261008/
https://www.ncbi.nlm.nih.gov/pubmed/35799292
http://dx.doi.org/10.1186/s40478-022-01387-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261008/
https://www.ncbi.nlm.nih.gov/pubmed/35799292
http://dx.doi.org/10.1186/s40478-022-01387-8

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