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Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition

The central role of an aberrantly activated EMT program in defining the critical features of aggressive carcinomas is well documented and includes cell plasticity, metastatic dissemination, drug resistance, and cancer stem cell-like phenotypes. The p53 tumor suppressor is critical for leashing off a...

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Detalles Bibliográficos
Autores principales: Semenov, Oleg, Daks, Alexandra, Fedorova, Olga, Shuvalov, Oleg, Barlev, Nickolai A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261265/
https://www.ncbi.nlm.nih.gov/pubmed/35813818
http://dx.doi.org/10.3389/fmolb.2022.928399