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Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition
The central role of an aberrantly activated EMT program in defining the critical features of aggressive carcinomas is well documented and includes cell plasticity, metastatic dissemination, drug resistance, and cancer stem cell-like phenotypes. The p53 tumor suppressor is critical for leashing off a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261265/ https://www.ncbi.nlm.nih.gov/pubmed/35813818 http://dx.doi.org/10.3389/fmolb.2022.928399 |
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author | Semenov, Oleg Daks, Alexandra Fedorova, Olga Shuvalov, Oleg Barlev, Nickolai A. |
author_facet | Semenov, Oleg Daks, Alexandra Fedorova, Olga Shuvalov, Oleg Barlev, Nickolai A. |
author_sort | Semenov, Oleg |
collection | PubMed |
description | The central role of an aberrantly activated EMT program in defining the critical features of aggressive carcinomas is well documented and includes cell plasticity, metastatic dissemination, drug resistance, and cancer stem cell-like phenotypes. The p53 tumor suppressor is critical for leashing off all the features mentioned above. On the molecular level, the suppression of these effects is exerted by p53 via regulation of its target genes, whose products are involved in cell cycle, apoptosis, autophagy, DNA repair, and interactions with immune cells. Importantly, a set of specific mutations in the TP53 gene (named Gain-of-Function mutations) converts this tumor suppressor into an oncogene. In this review, we attempted to contrast different regulatory roles of wild-type and mutant p53 in the multi-faceted process of EMT. |
format | Online Article Text |
id | pubmed-9261265 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92612652022-07-08 Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition Semenov, Oleg Daks, Alexandra Fedorova, Olga Shuvalov, Oleg Barlev, Nickolai A. Front Mol Biosci Molecular Biosciences The central role of an aberrantly activated EMT program in defining the critical features of aggressive carcinomas is well documented and includes cell plasticity, metastatic dissemination, drug resistance, and cancer stem cell-like phenotypes. The p53 tumor suppressor is critical for leashing off all the features mentioned above. On the molecular level, the suppression of these effects is exerted by p53 via regulation of its target genes, whose products are involved in cell cycle, apoptosis, autophagy, DNA repair, and interactions with immune cells. Importantly, a set of specific mutations in the TP53 gene (named Gain-of-Function mutations) converts this tumor suppressor into an oncogene. In this review, we attempted to contrast different regulatory roles of wild-type and mutant p53 in the multi-faceted process of EMT. Frontiers Media S.A. 2022-06-23 /pmc/articles/PMC9261265/ /pubmed/35813818 http://dx.doi.org/10.3389/fmolb.2022.928399 Text en Copyright © 2022 Semenov, Daks, Fedorova, Shuvalov and Barlev. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Semenov, Oleg Daks, Alexandra Fedorova, Olga Shuvalov, Oleg Barlev, Nickolai A. Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition |
title | Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition |
title_full | Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition |
title_fullStr | Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition |
title_full_unstemmed | Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition |
title_short | Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition |
title_sort | opposing roles of wild-type and mutant p53 in the process of epithelial to mesenchymal transition |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261265/ https://www.ncbi.nlm.nih.gov/pubmed/35813818 http://dx.doi.org/10.3389/fmolb.2022.928399 |
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