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mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases

The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a master regulator of metabolism and aging. A complex signaling network converges on mTORC1 and integrates growth factor, nutrient and stress signals. Aging is a dynamic process characterized by declining cellular survival, renewal, an...

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Autores principales: Cadena Sandoval, Marti, Heberle, Alexander Martin, Rehbein, Ulrike, Barile, Cecilia, Ramos Pittol, José Miguel, Thedieck, Kathrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261333/
https://www.ncbi.nlm.nih.gov/pubmed/35822040
http://dx.doi.org/10.3389/fragi.2021.761333
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author Cadena Sandoval, Marti
Heberle, Alexander Martin
Rehbein, Ulrike
Barile, Cecilia
Ramos Pittol, José Miguel
Thedieck, Kathrin
author_facet Cadena Sandoval, Marti
Heberle, Alexander Martin
Rehbein, Ulrike
Barile, Cecilia
Ramos Pittol, José Miguel
Thedieck, Kathrin
author_sort Cadena Sandoval, Marti
collection PubMed
description The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a master regulator of metabolism and aging. A complex signaling network converges on mTORC1 and integrates growth factor, nutrient and stress signals. Aging is a dynamic process characterized by declining cellular survival, renewal, and fertility. Stressors elicited by aging hallmarks such as mitochondrial malfunction, loss of proteostasis, genomic instability and telomere shortening impinge on mTORC1 thereby contributing to age-related processes. Stress granules (SGs) constitute a cytoplasmic non-membranous compartment formed by RNA-protein aggregates, which control RNA metabolism, signaling, and survival under stress. Increasing evidence reveals complex crosstalk between the mTORC1 network and SGs. In this review, we cover stressors elicited by aging hallmarks that impinge on mTORC1 and SGs. We discuss their interplay, and we highlight possible links in the context of aging and age-related diseases.
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spelling pubmed-92613332022-07-11 mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases Cadena Sandoval, Marti Heberle, Alexander Martin Rehbein, Ulrike Barile, Cecilia Ramos Pittol, José Miguel Thedieck, Kathrin Front Aging Aging The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a master regulator of metabolism and aging. A complex signaling network converges on mTORC1 and integrates growth factor, nutrient and stress signals. Aging is a dynamic process characterized by declining cellular survival, renewal, and fertility. Stressors elicited by aging hallmarks such as mitochondrial malfunction, loss of proteostasis, genomic instability and telomere shortening impinge on mTORC1 thereby contributing to age-related processes. Stress granules (SGs) constitute a cytoplasmic non-membranous compartment formed by RNA-protein aggregates, which control RNA metabolism, signaling, and survival under stress. Increasing evidence reveals complex crosstalk between the mTORC1 network and SGs. In this review, we cover stressors elicited by aging hallmarks that impinge on mTORC1 and SGs. We discuss their interplay, and we highlight possible links in the context of aging and age-related diseases. Frontiers Media S.A. 2021-10-13 /pmc/articles/PMC9261333/ /pubmed/35822040 http://dx.doi.org/10.3389/fragi.2021.761333 Text en Copyright © 2021 Cadena Sandoval, Heberle, Rehbein, Barile, Ramos Pittol and Thedieck. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging
Cadena Sandoval, Marti
Heberle, Alexander Martin
Rehbein, Ulrike
Barile, Cecilia
Ramos Pittol, José Miguel
Thedieck, Kathrin
mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases
title mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases
title_full mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases
title_fullStr mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases
title_full_unstemmed mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases
title_short mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases
title_sort mtorc1 crosstalk with stress granules in aging and age-related diseases
topic Aging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261333/
https://www.ncbi.nlm.nih.gov/pubmed/35822040
http://dx.doi.org/10.3389/fragi.2021.761333
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