Removal of p16 ( INK4 ) Expressing Cells in Late Life has Moderate Beneficial Effects on Skeletal Muscle Function in Male Mice

Aging results in the progressive accumulation of senescent cells in tissues that display loss of proliferative capacity and acquire a senescence-associated secretory phenotype (SASP). The tumor suppressor, p16( INK4A ), which slows the progression of the cell cycle, is highly expressed in most senes...

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Detalles Bibliográficos
Autores principales: Guzman, Steve D., Judge, Jennifer, Shigdar, Shahjahan M., Paul, Thomas A., Davis, Carol S., Macpherson, Peter C., Markworth, James F., Van Remmen, Holly, Richardson, Arlan, McArdle, Anne, Brooks, Susan V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Aging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261355/
https://www.ncbi.nlm.nih.gov/pubmed/35821997
http://dx.doi.org/10.3389/fragi.2021.821904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261355/
https://www.ncbi.nlm.nih.gov/pubmed/35821997
http://dx.doi.org/10.3389/fragi.2021.821904

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