G-quadruplexes Stabilization Upregulates CCN1 and Accelerates Aging in Cultured Cerebral Endothelial Cells

Senescence in the cerebral endothelium has been proposed as a mechanism that can drive dysfunction of the cerebral vasculature, which precedes vascular dementia. Cysteine-rich angiogenic inducer 61 (Cyr61/CCN1) is a matricellular protein secreted by cerebral endothelial cells (CEC). CCN1 induces sen...

Descripción completa

Detalles Bibliográficos
Autores principales: Noh, Brian, Blasco-Conesa, Maria P., Lai, Yun-Ju, Ganesh, Bhanu Priya, Urayama, Akihiko, Moreno-Gonzalez, Ines, Marrelli, Sean P., McCullough, Louise D., Moruno-Manchon, Jose Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Aging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261356/
https://www.ncbi.nlm.nih.gov/pubmed/35822045
http://dx.doi.org/10.3389/fragi.2021.797562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261356/
https://www.ncbi.nlm.nih.gov/pubmed/35822045
http://dx.doi.org/10.3389/fragi.2021.797562

Ejemplares similares