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G-quadruplexes Stabilization Upregulates CCN1 and Accelerates Aging in Cultured Cerebral Endothelial Cells

Senescence in the cerebral endothelium has been proposed as a mechanism that can drive dysfunction of the cerebral vasculature, which precedes vascular dementia. Cysteine-rich angiogenic inducer 61 (Cyr61/CCN1) is a matricellular protein secreted by cerebral endothelial cells (CEC). CCN1 induces sen...

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Detalles Bibliográficos
Autores principales:	Noh, Brian, Blasco-Conesa, Maria P., Lai, Yun-Ju, Ganesh, Bhanu Priya, Urayama, Akihiko, Moreno-Gonzalez, Ines, Marrelli, Sean P., McCullough, Louise D., Moruno-Manchon, Jose Felix
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Aging
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261356/ https://www.ncbi.nlm.nih.gov/pubmed/35822045 http://dx.doi.org/10.3389/fragi.2021.797562

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