Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera

Due to differences in human and murine angiotensin converting enzyme 2 (ACE-2) receptor, initially available SARS-CoV-2 isolates could not infect mice. Here we show that serial passaging of USA-WA1/2020 strain in mouse lungs results in “mouse-adapted” SARS-CoV-2 (MA-SARS-CoV-2) with mutations in S,...

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Detalles Bibliográficos
Autores principales: Rathnasinghe, Raveen, Jangra, Sonia, Ye, Chengjin, Cupic, Anastasija, Singh, Gagandeep, Martínez-Romero, Carles, Mulder, Lubbertus C. F., Kehrer, Thomas, Yildiz, Soner, Choi, Angela, Yeung, Stephen T., Mena, Ignacio, Gillespie, Virginia, De Vrieze, Jana, Aslam, Sadaf, Stadlbauer, Daniel, Meekins, David A., McDowell, Chester D., Balaraman, Velmurugan, Corley, Michael J., Richt, Juergen A., De Geest, Bruno G., Miorin, Lisa, Krammer, Florian, Martinez-Sobrido, Luis, Simon, Viviana, García-Sastre, Adolfo, Schotsaert, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261898/
https://www.ncbi.nlm.nih.gov/pubmed/35798721
http://dx.doi.org/10.1038/s41467-022-30763-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261898/
https://www.ncbi.nlm.nih.gov/pubmed/35798721
http://dx.doi.org/10.1038/s41467-022-30763-0

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