Disease-associated astrocytes in Alzheimer’s disease and aging

The role of non-neuronal cells in Alzheimer’s disease (AD) progression has not been fully elucidated. Using single-nucleus RNA-seq, we identified a population of disease associated astrocytes (DAAs) in an AD mouse model. The DAA population appeared at early disease stages and increased in abundance...

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Detalles Bibliográficos
Autores principales: Habib, Naomi, McCabe, Cristin, Medina, Sedi, Varshavsky, Miriam, Kitsberg, Daniel, Dvir-Szternfeld, Raz, Green, Gilad, Dionne, Danielle, Nguyen, Lan, Marshall, Jamie L., Chen, Fei, Zhang, Feng, Kaplan, Tommy, Regev, Aviv, Schwartz, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262034/
https://www.ncbi.nlm.nih.gov/pubmed/32341542
http://dx.doi.org/10.1038/s41593-020-0624-8
Descripción
Sumario:The role of non-neuronal cells in Alzheimer’s disease (AD) progression has not been fully elucidated. Using single-nucleus RNA-seq, we identified a population of disease associated astrocytes (DAAs) in an AD mouse model. The DAA population appeared at early disease stages and increased in abundance with age. We discovered that similar astrocytes appeared in aged wild-type mice and in aging human brains, suggesting their linkage to genetic and age-related factors.

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