Disease-associated astrocytes in Alzheimer’s disease and aging

The role of non-neuronal cells in Alzheimer’s disease (AD) progression has not been fully elucidated. Using single-nucleus RNA-seq, we identified a population of disease associated astrocytes (DAAs) in an AD mouse model. The DAA population appeared at early disease stages and increased in abundance...

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Autores principales: Habib, Naomi, McCabe, Cristin, Medina, Sedi, Varshavsky, Miriam, Kitsberg, Daniel, Dvir-Szternfeld, Raz, Green, Gilad, Dionne, Danielle, Nguyen, Lan, Marshall, Jamie L., Chen, Fei, Zhang, Feng, Kaplan, Tommy, Regev, Aviv, Schwartz, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262034/
https://www.ncbi.nlm.nih.gov/pubmed/32341542
http://dx.doi.org/10.1038/s41593-020-0624-8
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author Habib, Naomi
McCabe, Cristin
Medina, Sedi
Varshavsky, Miriam
Kitsberg, Daniel
Dvir-Szternfeld, Raz
Green, Gilad
Dionne, Danielle
Nguyen, Lan
Marshall, Jamie L.
Chen, Fei
Zhang, Feng
Kaplan, Tommy
Regev, Aviv
Schwartz, Michal
author_facet Habib, Naomi
McCabe, Cristin
Medina, Sedi
Varshavsky, Miriam
Kitsberg, Daniel
Dvir-Szternfeld, Raz
Green, Gilad
Dionne, Danielle
Nguyen, Lan
Marshall, Jamie L.
Chen, Fei
Zhang, Feng
Kaplan, Tommy
Regev, Aviv
Schwartz, Michal
author_sort Habib, Naomi
collection PubMed
description The role of non-neuronal cells in Alzheimer’s disease (AD) progression has not been fully elucidated. Using single-nucleus RNA-seq, we identified a population of disease associated astrocytes (DAAs) in an AD mouse model. The DAA population appeared at early disease stages and increased in abundance with age. We discovered that similar astrocytes appeared in aged wild-type mice and in aging human brains, suggesting their linkage to genetic and age-related factors.
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spelling pubmed-92620342022-07-07 Disease-associated astrocytes in Alzheimer’s disease and aging Habib, Naomi McCabe, Cristin Medina, Sedi Varshavsky, Miriam Kitsberg, Daniel Dvir-Szternfeld, Raz Green, Gilad Dionne, Danielle Nguyen, Lan Marshall, Jamie L. Chen, Fei Zhang, Feng Kaplan, Tommy Regev, Aviv Schwartz, Michal Nat Neurosci Article The role of non-neuronal cells in Alzheimer’s disease (AD) progression has not been fully elucidated. Using single-nucleus RNA-seq, we identified a population of disease associated astrocytes (DAAs) in an AD mouse model. The DAA population appeared at early disease stages and increased in abundance with age. We discovered that similar astrocytes appeared in aged wild-type mice and in aging human brains, suggesting their linkage to genetic and age-related factors. 2020-06 2020-04-27 /pmc/articles/PMC9262034/ /pubmed/32341542 http://dx.doi.org/10.1038/s41593-020-0624-8 Text en http://www.nature.com/authors/editorial_policies/license.html#termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Habib, Naomi
McCabe, Cristin
Medina, Sedi
Varshavsky, Miriam
Kitsberg, Daniel
Dvir-Szternfeld, Raz
Green, Gilad
Dionne, Danielle
Nguyen, Lan
Marshall, Jamie L.
Chen, Fei
Zhang, Feng
Kaplan, Tommy
Regev, Aviv
Schwartz, Michal
Disease-associated astrocytes in Alzheimer’s disease and aging
title Disease-associated astrocytes in Alzheimer’s disease and aging
title_full Disease-associated astrocytes in Alzheimer’s disease and aging
title_fullStr Disease-associated astrocytes in Alzheimer’s disease and aging
title_full_unstemmed Disease-associated astrocytes in Alzheimer’s disease and aging
title_short Disease-associated astrocytes in Alzheimer’s disease and aging
title_sort disease-associated astrocytes in alzheimer’s disease and aging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262034/
https://www.ncbi.nlm.nih.gov/pubmed/32341542
http://dx.doi.org/10.1038/s41593-020-0624-8
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