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Simplifying MS1 and MS2 spectra to achieve lower mass error, more dynamic range, and higher peptide identification confidence on the Bruker timsTOF Pro

For bottom-up proteomic analysis, the goal of analytical pipelines that process the raw output of mass spectrometers is to detect, characterise, identify, and quantify peptides. The initial steps of detecting and characterising features in raw data must overcome some considerable challenges. The dat...

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Detalles Bibliográficos
Autores principales: Wilding-McBride, Daryl, Dagley, Laura F., Spall, Sukhdeep K., Infusini, Giuseppe, Webb, Andrew I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262215/
https://www.ncbi.nlm.nih.gov/pubmed/35797390
http://dx.doi.org/10.1371/journal.pone.0271025