Multiple modes of antigen exposure induce clonotypically diverse epitope-specific CD8(+) T cells across multiple tissues in nonhuman primates

Antigen-specific CD8(+) T cells play a key role in the host’s antiviral response. T cells recognize viral epitopes via the T cell receptor (TCR), which contains the complementarity-determining region-3 (CDR3), comprising the variable, diversity and joining regions of the TCRβ gene. During chronic si...

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Detalles Bibliográficos
Autores principales: Simpson, Jennifer, Starke, Carly E., Ortiz, Alexandra M., Ransier, Amy, Darko, Sam, Douek, Daniel C., Brenchley, Jason M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262242/
https://www.ncbi.nlm.nih.gov/pubmed/35797339
http://dx.doi.org/10.1371/journal.ppat.1010611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262242/
https://www.ncbi.nlm.nih.gov/pubmed/35797339
http://dx.doi.org/10.1371/journal.ppat.1010611

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