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Multiple modes of antigen exposure induce clonotypically diverse epitope-specific CD8(+) T cells across multiple tissues in nonhuman primates
Antigen-specific CD8(+) T cells play a key role in the host’s antiviral response. T cells recognize viral epitopes via the T cell receptor (TCR), which contains the complementarity-determining region-3 (CDR3), comprising the variable, diversity and joining regions of the TCRβ gene. During chronic si...
Autores principales: | Simpson, Jennifer, Starke, Carly E., Ortiz, Alexandra M., Ransier, Amy, Darko, Sam, Douek, Daniel C., Brenchley, Jason M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262242/ https://www.ncbi.nlm.nih.gov/pubmed/35797339 http://dx.doi.org/10.1371/journal.ppat.1010611 |
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