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Predictions and experimental tests of a new biophysical model of the mammalian respiratory oscillator

Previously our computational modeling studies (Phillips et al., 2019) proposed that neuronal persistent sodium current (I(NaP)) and calcium-activated non-selective cation current (I(CAN)) are key biophysical factors that, respectively, generate inspiratory rhythm and burst pattern in the mammalian p...

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Detalles Bibliográficos
Autores principales: Phillips, Ryan S, Koizumi, Hidehiko, Molkov, Yaroslav I, Rubin, Jonathan E, Smith, Jeffrey C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262387/
https://www.ncbi.nlm.nih.gov/pubmed/35796425
http://dx.doi.org/10.7554/eLife.74762