Ribodysgenesis: sudden genome instability in the yeast Saccharomyces cerevisiae arising from RNase H2 cleavage at genomic-embedded ribonucleotides

Ribonucleotides can be incorporated into DNA during replication by the replicative DNA polymerases. These aberrant DNA subunits are efficiently recognized and removed by Ribonucleotide Excision Repair, which is initiated by the heterotrimeric enzyme RNase H2. While RNase H2 is essential in higher eu...

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Detalles Bibliográficos
Autores principales: Sui, Yang, Epstein, Anastasiya, Dominska, Margaret, Zheng, Dao-Qiong, Petes, Thomas D, Klein, Hannah L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262587/
https://www.ncbi.nlm.nih.gov/pubmed/35748861
http://dx.doi.org/10.1093/nar/gkac536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262587/
https://www.ncbi.nlm.nih.gov/pubmed/35748861
http://dx.doi.org/10.1093/nar/gkac536

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