Cargando…

Ribodysgenesis: sudden genome instability in the yeast Saccharomyces cerevisiae arising from RNase H2 cleavage at genomic-embedded ribonucleotides

Ribonucleotides can be incorporated into DNA during replication by the replicative DNA polymerases. These aberrant DNA subunits are efficiently recognized and removed by Ribonucleotide Excision Repair, which is initiated by the heterotrimeric enzyme RNase H2. While RNase H2 is essential in higher eu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sui, Yang, Epstein, Anastasiya, Dominska, Margaret, Zheng, Dao-Qiong, Petes, Thomas D, Klein, Hannah L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262587/ https://www.ncbi.nlm.nih.gov/pubmed/35748861 http://dx.doi.org/10.1093/nar/gkac536

Ejemplares similares

Abasic and oxidized ribonucleotides embedded in DNA are processed by human APE1 and not by RNase H2
por: Malfatti, Matilde Clarissa, et al.
Publicado: (2017)

Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity
por: Mentegari, Elisa, et al.
Publicado: (2017)

High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase
por: Cerritelli, Susana M, et al.
Publicado: (2020)

Mms1 binds to G-rich regions in Saccharomyces cerevisiae and influences replication and genome stability
por: Wanzek, Katharina, et al.
Publicado: (2017)

RNase H2 roles in genome integrity revealed by unlinking its activities
por: Chon, Hyongi, et al.
Publicado: (2013)

Genome-wide analysis of genomic alterations induced by oxidative DNA damage in yeast
por: Zhang, Ke, et al.
Publicado: (2019)

Do replication forks control late origin firing in Saccharomyces cerevisiae?
por: Ma, Emilie, et al.
Publicado: (2012)

R-loop formation by dCas9 is mutagenic in Saccharomyces cerevisiae
por: Laughery, Marian F, et al.
Publicado: (2019)

Two pathways drive meiotic chromosome axis assembly in Saccharomyces cerevisiae
por: Heldrich, Jonna, et al.
Publicado: (2022)

Functional analyses of the C-terminal half of the Saccharomyces cerevisiae Rad52 protein
por: Kagawa, Wataru, et al.
Publicado: (2014)

Evidence for double-strand break mediated mitochondrial DNA replication in Saccharomyces cerevisiae
por: Prasai, Kanchanjunga, et al.
Publicado: (2017)

Genetic instability triggered by G-quadruplex interacting Phen-DC compounds in Saccharomyces cerevisiae
por: Piazza, Aurèle, et al.
Publicado: (2010)

Recombinase-independent chromosomal rearrangements between dispersed inverted repeats in Saccharomyces cerevisiae meiosis
por: Allison, Rachal M, et al.
Publicado: (2023)

A polar filter in DNA polymerases prevents ribonucleotide incorporation
por: Johnson, Mary K, et al.
Publicado: (2019)

Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae
por: Ha, Cheol Woong, et al.
Publicado: (2011)

Rad10 exhibits lesion-dependent genetic requirements for recruitment to DNA double-strand breaks in Saccharomyces cerevisiae
por: Moore, Destaye M., et al.
Publicado: (2009)

The Saccharomyces cerevisiae Dna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replication
por: Levikova, Maryna, et al.
Publicado: (2015)

The fidelity of DNA replication, particularly on GC-rich templates, is reduced by defects of the Fe–S cluster in DNA polymerase δ
por: Kiktev, Denis A, et al.
Publicado: (2021)

Parallel analysis of ribonucleotide-dependent deletions produced by yeast Top1 in vitro and in vivo
por: Cho, Jang-Eun, et al.
Publicado: (2016)

A truncated DNA-damage-signaling response is activated after DSB formation in the G1 phase of Saccharomyces cerevisiae
por: Janke, Ryan, et al.
Publicado: (2010)

The β-1,3-glucanosyltransferase Gas1 regulates Sir2-mediated rDNA stability in Saccharomyces cerevisiae
por: Ha, Cheol Woong, et al.
Publicado: (2014)

The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage
por: Andreson, Bethany L., et al.
Publicado: (2010)

Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model
por: Moss, Chloe F., et al.
Publicado: (2017)

Histone H3 Lys79 methylation is required for efficient nucleotide excision repair in a silenced locus of Saccharomyces cerevisiae
por: Chaudhuri, Shubho, et al.
Publicado: (2009)

PCNA monoubiquitylation and DNA polymerase η ubiquitin-binding domain are required to prevent 8-oxoguanine-induced mutagenesis in Saccharomyces cerevisiae
por: van der Kemp, Patricia Auffret, et al.
Publicado: (2009)

The signature motif of the Saccharomyces cerevisiae Pif1 DNA helicase is essential in vivo for mitochondrial and nuclear functions and in vitro for ATPase activity
por: Geronimo, Carly L, et al.
Publicado: (2018)

The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 ‘gate’
por: Bochman, Matthew L., et al.
Publicado: (2010)

Saccharomyces cerevisiae DNA polymerase IV overcomes Rad51 inhibition of DNA polymerase δ in Rad52-mediated direct-repeat recombination
por: Cerqueira, Paula G, et al.
Publicado: (2023)

Assembly of a fragmented ribonucleotide reductase by protein interaction domains derived from a mobile genetic element
por: Crona, Mikael, et al.
Publicado: (2011)

Hug1 is an intrinsically disordered protein that inhibits ribonucleotide reductase activity by directly binding Rnr2 subunit
por: Meurisse, Julie, et al.
Publicado: (2014)

Novel alternative ribonucleotide excision repair pathways in human cells by DDX3X and specialized DNA polymerases
por: Riva, Valentina, et al.
Publicado: (2020)

Novel ribonucleotide discrimination in the RNA polymerase-like two-barrel catalytic core of Family D DNA polymerases
por: Zatopek, Kelly M, et al.
Publicado: (2020)

Genome-wide single-cell-level screen for protein abundance and localization changes in response to DNA damage in S. cerevisiae
por: Mazumder, Aprotim, et al.
Publicado: (2013)

Topoisomerase 1-dependent deletions initiated by incision at ribonucleotides are biased to the non-transcribed strand of a highly activated reporter
por: Cho, Jang-Eun, et al.
Publicado: (2015)

Repair of UV-induced DNA lesions in natural Saccharomyces cerevisiae telomeres is moderated by Sir2 and Sir3, and inhibited by yKu–Sir4 interaction
por: Guintini, Laetitia, et al.
Publicado: (2017)

Histone H3 K79 methylation states play distinct roles in UV-induced sister chromatid exchange and cell cycle checkpoint arrest in Saccharomyces cerevisiae
por: Rossodivita, Alyssa A., et al.
Publicado: (2014)

The amino-terminal tails of histones H2A and H3 coordinate efficient base excision repair, DNA damage signaling and postreplication repair in Saccharomyces cerevisiae
por: Meas, Rithy, et al.
Publicado: (2015)

PCNA directs type 2 RNase H activity on DNA replication and repair substrates
por: Bubeck, Doryen, et al.
Publicado: (2011)

Characterization of three mycobacterial DinB (DNA polymerase IV) paralogs highlights DinB2 as naturally adept at ribonucleotide incorporation
por: Ordonez, Heather, et al.
Publicado: (2014)

Effects of DNA(3′)pp(5′)G capping on 3′ end repair reactions and of an embedded pyrophosphate-linked guanylate on ribonucleotide surveillance
por: Chauleau, Mathieu, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_4asn7kolvuarjmm8gn8t055ft0