Mechanism of lesion verification by the human XPD helicase in nucleotide excision repair

In nucleotide excision repair (NER), the xeroderma pigmentosum D helicase (XPD) scans DNA searching for bulky lesions, stalls when encountering such damage to verify its presence, and allows repair to proceed. Structural studies have shown XPD bound to its single-stranded DNA substrate, but molecula...

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Detalles Bibliográficos
Autores principales: Fu, Iwen, Mu, Hong, Geacintov, Nicholas E, Broyde, Suse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262607/
https://www.ncbi.nlm.nih.gov/pubmed/35713557
http://dx.doi.org/10.1093/nar/gkac496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262607/
https://www.ncbi.nlm.nih.gov/pubmed/35713557
http://dx.doi.org/10.1093/nar/gkac496

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