Genome-wide CRISPR/Cas9 transcriptional activation screen identifies a histone acetyltransferase inhibitor complex as a regulator of HIV-1 integration

The retrovirus human immunodeficiency virus-1 (HIV-1) is the causative agent of AIDS. Although treatment of HIV/AIDS with antiretroviral therapy provides suppression of viremia, latent reservoirs of integrated proviruses preclude cure by current antiviral treatments. Understanding the mechanisms of...

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Detalles Bibliográficos
Autores principales: Zhang, Qiong, Wang, Shaobo, Li, Wanyu, Yau, Edwin, Hui, Hui, Singh, Parmit Kumar, Achuthan, Vasudevan, Young Karris, Maile Ann, Engelman, Alan N, Rana, Tariq M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262610/
https://www.ncbi.nlm.nih.gov/pubmed/35713529
http://dx.doi.org/10.1093/nar/gkac464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262610/
https://www.ncbi.nlm.nih.gov/pubmed/35713529
http://dx.doi.org/10.1093/nar/gkac464

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