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Fancd2os Reduces Testosterone Production by Inhibiting Steroidogenic Enzymes and Promoting Cellular Apoptosis in Murine Testicular Leydig Cells

BACKGROUND: It is well-established that serum testosterone in men decreases with age, yet the underlying mechanism of this change remains elusive. METHODS: The expression patterns of Fancd2 opposite-strand (Fancd2os) in BALB/c male mice and testicular tissue derived cell lines (GC-1, GC-2, TM3, and...

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Detalles Bibliográficos
Autores principales: Zhai, Xiang, Li, Xin-yang, Wang, Yu-jing, Qin, Ke-ru, Hu, Jin-rui, Li, Mei-ning, Wang, Hai-long, Guo, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Endocrine Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262688/
https://www.ncbi.nlm.nih.gov/pubmed/35798552
http://dx.doi.org/10.3803/EnM.2022.1431