KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization

The KH-type splicing regulatory protein (KHSRP) is an RNA-binding protein linked to decay of mRNAs with AU-rich elements. KHSRP was previously shown to destabilize Gap43 mRNA and decrease neurite growth in cultured embryonic neurons. Here, we have tested functions of KHSRP in vivo. We find upregulat...

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Detalles Bibliográficos
Autores principales: Olguin, Sarah L., Patel, Priyanka, Buchanan, Courtney N., Dell’Orco, Michela, Gardiner, Amy S., Cole, Robert, Vaughn, Lauren S., Sundararajan, Anitha, Mudge, Joann, Allan, Andrea M., Ortinski, Pavel, Brigman, Jonathan L., Twiss, Jeffery L., Perrone-Bizzozero, Nora I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262970/
https://www.ncbi.nlm.nih.gov/pubmed/35798971
http://dx.doi.org/10.1038/s42003-022-03594-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262970/
https://www.ncbi.nlm.nih.gov/pubmed/35798971
http://dx.doi.org/10.1038/s42003-022-03594-4

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