Synchronous intracellular delivery of EGFR-targeted antibody–drug conjugates by p38-mediated non-canonical endocytosis

Monoclonal antibodies targeting the epidermal growth factor receptor (EGFR), including cetuximab and panitumumab, have been used in clinic settings to treat cancer. They have also recently been applied to antibody–drug conjugates (ADCs); however, their clinical efficacy is limited by several issues,...

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Detalles Bibliográficos
Autores principales: Takahashi, Jun-ichiro, Nakamura, Shiori, Onuma, Iimi, Zhou, Yue, Yokoyama, Satoru, Sakurai, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262980/
https://www.ncbi.nlm.nih.gov/pubmed/35798841
http://dx.doi.org/10.1038/s41598-022-15838-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262980/
https://www.ncbi.nlm.nih.gov/pubmed/35798841
http://dx.doi.org/10.1038/s41598-022-15838-8

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