Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons

Deficits in axonal transport are one of the earliest pathological outcomes in several models of amyotrophic lateral sclerosis (ALS), including SOD1(G93A) mice. Evidence suggests that rescuing these deficits prevents disease progression, stops denervation, and extends survival. Kinase inhibitors have...

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Detalles Bibliográficos
Autores principales: Rhymes, Elena R., Tosolini, Andrew P., Fellows, Alexander D., Mahy, William, McDonald, Neil Q., Schiavo, Giampietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263112/
https://www.ncbi.nlm.nih.gov/pubmed/35798698
http://dx.doi.org/10.1038/s41419-022-05031-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263112/
https://www.ncbi.nlm.nih.gov/pubmed/35798698
http://dx.doi.org/10.1038/s41419-022-05031-0

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