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TGFβ reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis

It is well-established that receptor activator of NF-κB ligand (RANKL) is the inducer of physiological osteoclast differentiation. However, the specific drivers and mechanisms driving inflammatory osteoclast differentiation under pathological conditions remain obscure. This is especially true given...

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Detalles Bibliográficos
Autores principales: Xia, Yuhan, Inoue, Kazuki, Du, Yong, Baker, Stacey J., Reddy, E. Premkumar, Greenblatt, Matthew B., Zhao, Baohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263175/
https://www.ncbi.nlm.nih.gov/pubmed/35798734
http://dx.doi.org/10.1038/s41467-022-31475-1

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