Discovery of Small Molecule KCC2 Potentiators Which Attenuate In Vitro Seizure-Like Activity in Cultured Neurons

KCC2 is a K(+)-Cl(−) cotransporter that is expressed in neurons throughout the central nervous system. Deficits in KCC2 activity have been implicated in a variety of neurological disorders, including epilepsy, chronic pain, autism spectrum disorders, and Rett syndrome. Therefore, it has been hypothe...

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Detalles Bibliográficos
Autores principales: Prael III, Francis J., Kim, Kwangho, Du, Yu, Spitznagel, Brittany D., Sulikowski, Gary A., Delpire, Eric, Weaver, C. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263442/
https://www.ncbi.nlm.nih.gov/pubmed/35813195
http://dx.doi.org/10.3389/fcell.2022.912812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263442/
https://www.ncbi.nlm.nih.gov/pubmed/35813195
http://dx.doi.org/10.3389/fcell.2022.912812

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