Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1

Preeclampsia (PE) is a rising, potentially lethal complication of pregnancy. PE is driven primarily by the overexpression of placental soluble fms-like tyrosine kinase 1 (sFLT1), a validated diagnostic and prognostic marker of the disease when normalized to placental growth factor (PlGF) levels. Inj...

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Detalles Bibliográficos
Autores principales: Davis, Sarah M., Hariharan, Vignesh N., Lo, Agnes, Turanov, Anton A., Echeverria, Dimas, Sousa, Jacquelyn, McHugh, Nicholas, Biscans, Annabelle, Alterman, Julia F., Karumanchi, S. Ananth, Moore, Melissa J., Khvorova, Anastasia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263991/
https://www.ncbi.nlm.nih.gov/pubmed/35847173
http://dx.doi.org/10.1016/j.omtn.2022.06.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263991/
https://www.ncbi.nlm.nih.gov/pubmed/35847173
http://dx.doi.org/10.1016/j.omtn.2022.06.009

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