Pd-catalyzed C–C and C–N cross-coupling reactions in 2-aminothieno[3,2-d]pyrimidin-4(3H)-one series for antiplasmodial pharmacomodulation

In 2015, we identified gamhepathiopine (M1), a 2-tert-butylaminothieno[3,2-d]pyrimidin-4(3H)-one antiplasmodial hit targeting all development stages of the human malarial parasite P. falciparum. However, this hit compound suffers from sensitivity to hepatic oxidative metabolism. Herein, we describe...

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Detalles Bibliográficos
Autores principales: Mustière, Romain, Lagardère, Prisca, Hutter, Sébastien, Deraeve, Céline, Schwalen, Florian, Amrane, Dyhia, Masurier, Nicolas, Azas, Nadine, Lisowski, Vincent, Verhaeghe, Pierre, Mazier, Dominique, Vanelle, Patrice, Primas, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264115/
https://www.ncbi.nlm.nih.gov/pubmed/35865200
http://dx.doi.org/10.1039/d2ra01687g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264115/
https://www.ncbi.nlm.nih.gov/pubmed/35865200
http://dx.doi.org/10.1039/d2ra01687g

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