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Phase I/II study of streptozocin monotherapy in Japanese patients with unresectable or metastatic gastroenteropancreatic neuroendocrine tumors

BACKGROUND: This phase I/II study was conducted to evaluate the efficacy, safety and pharmacokinetics of streptozocin (STZ) in Japanese patients with unresectable or metastatic gastroenteropancreatic neuroendocrine tumors. METHODS: Twenty-two patients received up to 4 cycles of intravenous STZ at ei...

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Detalles Bibliográficos
Autores principales: Komoto, Izumi, Kokudo, Norihiro, Aoki, Taku, Morizane, Chigusa, Ito, Tetsuhide, Hashimoto, Takuya, Kimura, Wataru, Inoue, Naoya, Hasegawa, Kiyoshi, Kondo, Shunsuke, Ueno, Hideki, Igarashi, Hisato, Oono, Takamasa, Makuuchi, Masatoshi, Takamoto, Takeshi, Hirai, Ichiro, Takeshita, Akiko, Imamura, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264336/
https://www.ncbi.nlm.nih.gov/pubmed/35411926
http://dx.doi.org/10.1093/jjco/hyac048