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Protective Effects of Intranasally Administrated Oxytocin-Loaded Nanoparticles on Pentylenetetrazole-Kindling Epilepsy in Terms of Seizure Severity, Memory, Neurogenesis, and Neuronal Damage

[Image: see text] Pentylenetetrazole (PTZ)-induced kindling is an animal model for studying human temporal lobe epilepsy (TLE), which is characterized by alterations of hippocampal neurons and memory. Although the intranasal (IN) administration of oxytocin (OT) has limited efficiency, nanoparticles...

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Detalles Bibliográficos
Autores principales: Sahin, Hakan, Yucel, Oguz, Emik, Serkan, Senturk, Gozde Erkanli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264347/
https://www.ncbi.nlm.nih.gov/pubmed/35713692
http://dx.doi.org/10.1021/acschemneuro.2c00124