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Conformational Flexibility as a Tool for Enabling Site-Selective Functionalization of Unactivated sp(3) C–O Bonds in Cyclic Acetals
[Image: see text] A dual catalytic manifold that enables site-selective functionalization of unactivated sp(3) C–O bonds in cyclic acetals with aryl and alkyl halides is reported. The reaction is triggered by an appropriate σ*–p orbital overlap prior to sp(3) C–O cleavage, thus highlighting the impo...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264358/ https://www.ncbi.nlm.nih.gov/pubmed/35749319 http://dx.doi.org/10.1021/jacs.2c04513 |