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Cilia-localized GID/CTLH ubiquitin ligase complex regulates protein homeostasis of sonic hedgehog signaling components

Cilia are evolutionarily conserved organelles that orchestrate a variety of signal transduction pathways, such as sonic hedgehog (SHH) signaling, during embryonic development. Our recent studies have shown that loss of GID ubiquitin ligase function results in aberrant AMP-activated protein kinase (A...

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Detalles Bibliográficos
Autores principales: Hantel, Friederike, Liu, Huaize, Fechtner, Lisa, Neuhaus, Herbert, Ding, Jie, Arlt, Danilo, Walentek, Peter, Villavicencio-Lorini, Pablo, Gerhardt, Christoph, Hollemann, Thomas, Pfirrmann, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264362/
https://www.ncbi.nlm.nih.gov/pubmed/35543155
http://dx.doi.org/10.1242/jcs.259209