Chromatography at −30 °C for Reduced Back-Exchange, Reduced Carryover, and Improved Dynamic Range for Hydrogen–Deuterium Exchange Mass Spectrometry

[Image: see text] For hydrogen–deuterium exchange mass spectrometry (HDX-MS) to have an increased role in quality control of biopharmaceuticals, H for D back-exchange occurring during protein analyses should be minimized to promote greater reproducibility. Standard HDX-MS analysis systems that diges...

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Detalles Bibliográficos
Autores principales: Anderson, Kyle W., Hudgens, Jeffrey W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264389/
https://www.ncbi.nlm.nih.gov/pubmed/35732031
http://dx.doi.org/10.1021/jasms.2c00096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264389/
https://www.ncbi.nlm.nih.gov/pubmed/35732031
http://dx.doi.org/10.1021/jasms.2c00096

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