Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities

Understanding which biological pathways are specific versus general across diagnostic categories and levels of symptom severity is critical to improving nosology and treatment of psychopathology. Here, we combine transdiagnostic and dimensional approaches to genetic discovery for the first time, con...

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Detalles Bibliográficos
Autores principales: Mallard, Travis T., Karlsson Linnér, Richard, Grotzinger, Andrew D., Sanchez-Roige, Sandra, Seidlitz, Jakob, Okbay, Aysu, de Vlaming, Ronald, Meddens, S. Fleur W., Palmer, Abraham A., Davis, Lea K., Tucker-Drob, Elliot M., Kendler, Kenneth S., Keller, Matthew C., Koellinger, Philipp D., Harden, K. Paige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264403/
https://www.ncbi.nlm.nih.gov/pubmed/35812988
http://dx.doi.org/10.1016/j.xgen.2022.100140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264403/
https://www.ncbi.nlm.nih.gov/pubmed/35812988
http://dx.doi.org/10.1016/j.xgen.2022.100140

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