DeCAF: a novel method to identify cell-type specific regulatory variants and their role in cancer risk

Here, we propose DeCAF (DEconvoluted cell type Allele specific Function), a new method to identify cell-fraction (cf) QTLs in tumors by leveraging both allelic and total expression information. Applying DeCAF to RNA-seq data from TCGA, we identify 3664 genes with cfQTLs (at 10% FDR) in 14 cell types...

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Detalles Bibliográficos
Autores principales: Kalita, Cynthia A., Gusev, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264694/
https://www.ncbi.nlm.nih.gov/pubmed/35804456
http://dx.doi.org/10.1186/s13059-022-02708-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264694/
https://www.ncbi.nlm.nih.gov/pubmed/35804456
http://dx.doi.org/10.1186/s13059-022-02708-9

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