Novel Treatments of Uveal Melanoma Identified with a Synthetic Lethal CRISPR/Cas9 Screen

SIMPLE SUMMARY: We performed a CRISPR-Cas9 synthetic lethality screen in order to identify molecular targets whose inhibition would synergistically enhance the effect of everolimus in uveal melanoma cells. IGF1R and PRKDC, among others, were identified as hits. We verified these hits effects genetic...

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Detalles Bibliográficos
Autores principales: Glinkina, Kseniya, Groenewoud, Arwin, Teunisse, Amina F. A. S., Snaar-Jagalska, B. Ewa, Jochemsen, Aart G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264875/
https://www.ncbi.nlm.nih.gov/pubmed/35804957
http://dx.doi.org/10.3390/cancers14133186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264875/
https://www.ncbi.nlm.nih.gov/pubmed/35804957
http://dx.doi.org/10.3390/cancers14133186

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