Cargando…

The CBP/β-Catenin Antagonist, ICG-001, Inhibits Tumor Metastasis via Blocking of the miR-134/ITGB1 Axis-Mediated Cell Adhesion in Nasopharyngeal Carcinoma

SIMPLE SUMMARY: Metastatic nasopharyngeal carcinoma (NPC) is incurable and remains the main cause of NPC death. Our previous studies found that the CBP/β-catenin Wnt antagonist, IGC-001, could inhibit the primary tumor formation of NPC tumor cells. Here, we further explored the anti-metastatic activ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Luo, Chiang, Yiu Chun, Chan, Lai Sheung, Chau, Wai Yin, Lung, Maria Li, Kahn, Michael, Lo, Kwok Wai, Mak, Nai Ki, Lung, Hong Lok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264930/ https://www.ncbi.nlm.nih.gov/pubmed/35804897 http://dx.doi.org/10.3390/cancers14133125

Ejemplares similares

The β-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner
por: Wiese, Maria, et al.
Publicado: (2017)

Therapeutic targeting of CBP/β-catenin signaling reduces cancer stem-like population and synergistically suppresses growth of EBV-positive nasopharyngeal carcinoma cells with cisplatin
por: Chan, King Chi, et al.
Publicado: (2015)

Role of miR-96/EVI1/miR-449a Axis in the Nasopharyngeal Carcinoma Cell Migration and Tumor Sphere Formation
por: Chan, Lai-Sheung, et al.
Publicado: (2020)

Targeting Epstein-Barr Virus in Nasopharyngeal Carcinoma
por: Hau, Pok Man, et al.
Publicado: (2020)

Indocyanine Green-001 (ICG-001) Attenuates Wnt/β-catenin-induces Myocardial Injury Following Sepsis
por: Yousif, Nasser Ghaly, et al.
Publicado: (2017)

The anti-tumor function of the IKK inhibitor PS1145 and high levels of p65 and KLF4 are associated with the drug resistance in nasopharyngeal carcinoma cells
por: Lung, Hong Lok, et al.
Publicado: (2019)

β-catenin signaling inhibitors ICG-001 and C-82 improve fibrosis in preclinical models of endometriosis
por: Hirakawa, Tomoko, et al.
Publicado: (2019)

β-catenin inhibitors ICG-001 and pyrvinium sensitize bortezomib-resistant multiple myeloma cells to bortezomib
por: Wu, Cuicui
Publicado: (2022)

CBP/Catenin Antagonist Safely Eliminates Drug Resistant Leukemia Initiating Cells
por: Zhao, Yi, et al.
Publicado: (2015)

THY1 (CD90) Maintains the Adherens Junctions in Nasopharyngeal Carcinoma via Inhibition of SRC Activation
por: Chen, Luo, et al.
Publicado: (2023)

Combination of Auranofin and ICG-001 Suppress the Proliferation and Metastasis of Colon Cancer
por: Lin, Zhaoyan, et al.
Publicado: (2021)

The Small Molecule Wnt Signaling Modulator ICG-001 Improves Contractile Function in Chronically Infarcted Rat Myocardium
por: Sasaki, Tomoyo, et al.
Publicado: (2013)

KYA1797K, a Novel Small Molecule Destabilizing β-Catenin, Is Superior to ICG-001 in Protecting against Kidney Aging
por: Zhu, Mingsheng, et al.
Publicado: (2022)

ICG-001 Exerts Potent Anticancer Activity Against Uveal Melanoma Cells
por: Kaochar, Salma, et al.
Publicado: (2018)

EBNA1-targeted inhibitors: Novel approaches for the treatment of Epstein-Barr virus-associated cancers
por: Jiang, Lijun, et al.
Publicado: (2018)

MicroRNA profiling study reveals miR-150 in association with metastasis in nasopharyngeal carcinoma
por: Yue, Patrick Ying-Kit, et al.
Publicado: (2017)

Differentiation Therapy Targeting the β-Catenin/CBP Interaction in Pancreatic Cancer
por: Manegold, Philipp, et al.
Publicado: (2018)

ICG-001, an Inhibitor of the β-Catenin and cAMP Response Element-Binding Protein Dependent Gene Transcription, Decreases Proliferation but Enhances Migration of Osteosarcoma Cells
por: Danieau, Geoffroy, et al.
Publicado: (2021)

PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma
por: Cheung, Arthur Kwok Leung, et al.
Publicado: (2015)

miR-134-5p inhibits osteoclastogenesis through a novel miR-134-5p/Itgb1/MAPK pathway
por: Huang, Meng, et al.
Publicado: (2022)

The interplay of host genetic factors and Epstein-Barr virus in the development of nasopharyngeal carcinoma
por: Lung, Maria Li, et al.
Publicado: (2014)

EBV–encoded miRNAs can sensitize nasopharyngeal carcinoma to chemotherapeutic drugs by targeting BRCA1
por: Lung, Raymond Wai‐Ming, et al.
Publicado: (2020)

ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect
por: Zinecker, Heidi, et al.
Publicado: (2017)

EBV latent membrane protein 1 augments γδ T cell cytotoxicity against nasopharyngeal carcinoma by induction of butyrophilin molecules
por: Liu, Yue, et al.
Publicado: (2023)

CBP/β-Catenin/FOXM1 Is a Novel Therapeutic Target in Triple Negative Breast Cancer
por: Ring, Alexander, et al.
Publicado: (2018)

A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation
por: Chan, King Chi, et al.
Publicado: (2013)

Canonical Wnt Pathway Inhibitor ICG-001 Induces Cytotoxicity of Multiple Myeloma Cells in Wnt-Independent Manner
por: Grigson, Eileen R., et al.
Publicado: (2015)

ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population
por: Liu, Yi, et al.
Publicado: (2017)

ITGB1-DT Facilitates Lung Adenocarcinoma Progression via Forming a Positive Feedback Loop With ITGB1/Wnt/β-Catenin/MYC
por: Chang, Ruimin, et al.
Publicado: (2021)

The Transcriptional Coactivator Cbp Interacts with β-Catenin to Activate Gene Expression
por: Takemaru, Ken-Ichi, et al.
Publicado: (2000)

Fibroblast Growth Factor Receptor-Mediated Activation of AKT-β-Catenin-CBP Pathway Regulates Survival and Proliferation of Murine Hepatoblasts and Hepatic Tumor Initiating Stem Cells
por: Mavila, Nirmala, et al.
Publicado: (2012)

Nuclear receptor/Wnt beta-catenin interactions are regulated via differential CBP/p300 coactivator usage
por: Ono, Masaya, et al.
Publicado: (2018)

Systematic Variability in ICG Recordings Results in ICG Complex Subtypes – Steps Towards the Enhancement of ICG Characterization
por: Benouar, Sara, et al.
Publicado: (2018)

Convalescent blood plasma (CBP) donated by recovered COVID-19 patients – A comment
por: Lung, Th., et al.
Publicado: (2021)

NF-κB p65 Subunit Is Modulated by Latent Transforming Growth Factor-β Binding Protein 2 (LTBP2) in Nasopharyngeal Carcinoma HONE1 and HK1 Cells
por: Kan, Rebecca, et al.
Publicado: (2015)

The CREB-binding protein inhibitor ICG-001: a promising therapeutic strategy in sporadic meningioma with NF2 mutations
por: Deng, Jiaojiao, et al.
Publicado: (2020)

Activation of sterol regulatory element‐binding protein 1 (SREBP1)‐mediated lipogenesis by the Epstein–Barr virus‐encoded latent membrane protein 1 (LMP1) promotes cell proliferation and progression of nasopharyngeal carcinoma
por: Lo, Angela Kwok‐Fung, et al.
Publicado: (2018)

A regulatory circuit comprising the CBP and SIRT7 regulates FAM134B-mediated ER-phagy
por: Wang, Xinyi, et al.
Publicado: (2023)

Small molecule inhibition of CBP/catenin interactions eliminates drug resistant clones in acute lymphoblastic leukemia
por: Gang, Eun Ji, et al.
Publicado: (2013)

Inhibition of CBP/β‐catenin signaling ameliorated fibrosis in cholestatic liver disease
por: Kimura, Masamichi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_k0sdbpdf8ns2cinocodl6q1uh3