CDK4/CDK6 Inhibitors Synergize with Midostaurin, Avapritinib, and Nintedanib in Inducing Growth Inhibition in KIT D816V(+) Neoplastic Mast Cells

SIMPLE SUMMARY: Advanced systemic mastocytosis (AdvSM) is a rare malignant disease with a poor prognosis due to the drug resistance of neoplastic mast cells. We found that drugs targeting the cell cycle regulators CDK4 and CDK6 profoundly suppress the growth and survival of neoplastic mast cells. Fu...

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Detalles Bibliográficos
Autores principales: Schneeweiss-Gleixner, Mathias, Filik, Yüksel, Stefanzl, Gabriele, Berger, Daniela, Sadovnik, Irina, Bauer, Karin, Smiljkovic, Dubravka, Eisenwort, Gregor, Witzeneder, Nadine, Greiner, Georg, Hoermann, Gregor, Schiefer, Ana-Iris, Schwaab, Juliana, Jawhar, Mohamad, Reiter, Andreas, Sperr, Wolfgang R., Arock, Michel, Valent, Peter, Gleixner, Karoline V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264943/
https://www.ncbi.nlm.nih.gov/pubmed/35804842
http://dx.doi.org/10.3390/cancers14133070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264943/
https://www.ncbi.nlm.nih.gov/pubmed/35804842
http://dx.doi.org/10.3390/cancers14133070

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