Genetic Disruption of the γ-Glutamylcysteine Ligase in PDAC Cells Induces Ferroptosis-Independent Cell Death In Vitro without Affecting In Vivo Tumor Growth

SIMPLE SUMMARY: The newly described form of iron-dependent cell death, called ferroptosis, has emerged as a powerful strategy for eradicating cancer cells. This is of particular importance for pancreatic ductal adenocarcinoma (PDAC), which has been shown to be one of the most aggressive tumors, with...

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Detalles Bibliográficos
Autores principales: Daher, Boutaina, Meira, Willian, Durivault, Jerome, Gotorbe, Celia, Pouyssegur, Jacques, Vucetic, Milica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264981/
https://www.ncbi.nlm.nih.gov/pubmed/35804926
http://dx.doi.org/10.3390/cancers14133154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264981/
https://www.ncbi.nlm.nih.gov/pubmed/35804926
http://dx.doi.org/10.3390/cancers14133154

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