A Genome-First Approach to Estimate Prevalence of Germline Pathogenic Variants and Risk of Pancreatic Cancer in Select Cancer Susceptibility Genes

SIMPLE SUMMARY: Prevalence and cancer risk estimates derived from the evaluation of affected individuals in the clinic are subject to ascertainment bias. This limitation can be mitigated using a genome-first approach in which genotypic data is analyzed before knowing a patient’s phenotype. Our study...

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Detalles Bibliográficos
Autores principales: Astiazaran-Symonds, Esteban, Kim, Jung, Haley, Jeremy S., Kim, Sun Young, Rao, H. Shanker, Genetics Center, Regeneron, Carey, David J., Stewart, Douglas R., Goldstein, Alisa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265005/
https://www.ncbi.nlm.nih.gov/pubmed/35805029
http://dx.doi.org/10.3390/cancers14133257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265005/
https://www.ncbi.nlm.nih.gov/pubmed/35805029
http://dx.doi.org/10.3390/cancers14133257

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