Intestinal FXR Activation via Transgenic Chimera or Chemical Agonism Prevents Colitis-Associated and Genetically-Induced Colon Cancer

SIMPLE SUMMARY: Disruption of Bile Acids (BA) regulation with increased BA concentration and modulation or their detergent pro-inflammatory activity has been linked to colorectal cancer (CRC). Farnesoid X Receptor (FXR) is the master regulator of BA homeostasis; FXR is a nuclear receptor that transc...

Descripción completa

Detalles Bibliográficos
Autores principales: Cariello, Marica, Zerlotin, Roberta, Pasculli, Emanuela, Piccinin, Elena, Peres, Claudia, Porru, Emanuele, Roda, Aldo, Gadaleta, Raffaella Maria, Moschetta, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265121/
https://www.ncbi.nlm.nih.gov/pubmed/35804854
http://dx.doi.org/10.3390/cancers14133081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265121/
https://www.ncbi.nlm.nih.gov/pubmed/35804854
http://dx.doi.org/10.3390/cancers14133081

Ejemplares similares