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Intestinal FXR Activation via Transgenic Chimera or Chemical Agonism Prevents Colitis-Associated and Genetically-Induced Colon Cancer

SIMPLE SUMMARY: Disruption of Bile Acids (BA) regulation with increased BA concentration and modulation or their detergent pro-inflammatory activity has been linked to colorectal cancer (CRC). Farnesoid X Receptor (FXR) is the master regulator of BA homeostasis; FXR is a nuclear receptor that transc...

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Detalles Bibliográficos
Autores principales:	Cariello, Marica, Zerlotin, Roberta, Pasculli, Emanuela, Piccinin, Elena, Peres, Claudia, Porru, Emanuele, Roda, Aldo, Gadaleta, Raffaella Maria, Moschetta, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265121/ https://www.ncbi.nlm.nih.gov/pubmed/35804854 http://dx.doi.org/10.3390/cancers14133081

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